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EaseUS Backup Center Section

Supported Hard Disk Types

EaseUS Backup Center supports all IDE, EIDE, SATA, ESATA, ATA, SCSI, iSCSI, USB 1.1/2.0/3.0 disk, and Firewire disks. No matter how you manage the hard drive, Dynamic disk, MBR and GPT disks are all able to be used to install this tool. 

But considering a long run backup plan, it is better to install EaseUS Backup Center in a local internal hard drive.